Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[2-(1-Naphthalenyl)Acetyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel quinolone-based active pharmaceutical ingredients (APIs), offering a key building block for research and development. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antimicrobial and therapeutic agent discovery.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of next-generation fluoroquinolone antibiotics and other therapeutic agents.
• Antimicrobial Research: Serves as a core scaffold for developing novel compounds targeting bacterial DNA gyrase and topoisomerase IV.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of complex, high-value specialty chemicals.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for pharmacological and biochemical studies.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[2-(1-Naphthalenyl)Acetyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1053950-11-0
Molecular Formula	C₂₉H₂₆FN₃O₄
Molecular Weight	499.54 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[2-(1-naphthalenyl)acetyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(2-(naphthalen-1-yl)acetyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK-2140944 Intermediate; GSK2140944 Intermediate; 1053950-11-0; 1-Cyclopropyl-6-fluoro-7-[4-(2-naphth-1-ylacetyl)piperazin-1-yl]-4-oxo-1H-quinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.