Description

2,4,5-Trichloro-7H-Pyrrolo[2,3-d]pyrimidine is a high-purity halogenated heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a versatile and critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a scaffold for developing chemical probes and tool compounds to study biological pathways.
• Material Science Research: Investigated as a building block for organic electronic materials and advanced polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development candidates.
• Academic Research: Utilized in university and institutional labs for methodological development and discovery chemistry.

Basic Information

Product Name	2,4,5-Trichloro-7H-Pyrrolo[2,3-d]pyrimidine
CAS No.	1053228-28-6
Molecular Formula	C6H2Cl3N3
Molecular Weight	232.46 g/mol
Synonyms	2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro-; 2,4,5-Trichloropyrrolo[2,3-d]pyrimidine; 2,4,5-Trichloro-7-azaindole (common name); Trichloropyrrolopyrimidine; CAS 1053228-28-6
EINECS	Contact for details

Quality Control

Our 2,4,5-Trichloro-7H-Pyrrolo[2,3-d]pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder/crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.