Description

1-(Pentafluorophenyl)Piperazine, Hcl is a high-value, fluorinated piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in introducing the unique pentafluorophenyl group, which can significantly alter the physicochemical properties of target molecules, enhancing metabolic stability and binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in medicinal chemistry for creating potential drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorinated aromatic system contributes to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to the electron-withdrawing nature of the pentafluorophenyl group.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental research in fluorine chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	1-(Pentafluorophenyl)Piperazine, Hcl
CAS No.	1052530-86-5
Molecular Formula	C10H10ClF5N2
Molecular Weight	288.65 g/mol
Synonyms	1-(Pentafluorophenyl)piperazine hydrochloride; Piperazine, 1-(pentafluorophenyl)-, hydrochloride; 1-(Perfluorophenyl)piperazine hydrochloride; 4-(Pentafluorophenyl)piperazine hydrochloride; Pentafluorophenylpiperazine HCl; PFP-Piperazine HCl; 1052530-86-5 (CAS)
EINECS	Contact for details

Quality Control

Our 1-(Pentafluorophenyl)Piperazine, Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.