Description

(Des-Gly10,D-Leu6,Orn8,Pro-Nhet9)-Lhrh CAS NO 1051970-61-6 is a synthetic peptide analog of Gonadotropin-Releasing Hormone (GnRH), engineered with specific amino acid modifications to enhance its stability and biological activity. This compound is critical for advanced research in endocrinology and the development of targeted therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on reproductive health, oncology, and peptide-based drug discovery.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active ingredient in preclinical studies for novel GnRH-based therapies.
• Endocrinology Studies: Used in laboratory research to investigate the hypothalamic-pituitary-gonadal axis, hormone regulation, and receptor binding mechanisms.
• Oncology Research: Explored in the development of targeted treatments for hormone-dependent cancers, such as prostate and breast cancer.
• Peptide Drug Discovery: Acts as a model compound for studying structure-activity relationships (SAR) and optimizing peptide stability and delivery.
• Veterinary Medicine: Applied in research for animal reproductive management and fertility control.
• Biochemical Assay Development: Utilized as a critical component in the development and validation of immunoassays and bioassays.

Basic Information

Product Name	(Des-Gly10,D-Leu6,Orn8,Pro-Nhet9)-Lhrh
CAS No.	1051970-61-6
Molecular Formula	C58H82N16O12
Molecular Weight	~1171.4 g/mol
Synonyms	GnRH Analog; LHRH Antagonist Analog; (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-Luteinizing Hormone-Releasing Hormone; D-Leu6,Orn8,Pro-NHEt9-GnRH; Gonadorelin (6-D-Leucine, 8-L-Ornithine, 9-[N-ethyl-L-prolinamide]) analog; Peptide JV-1-36 (related analog); Azaline B derivative
EINECS	Contact for details

Quality Control

Every batch of our (Des-Gly10,D-Leu6,Orn8,Pro-Nhet9)-Lhrh is manufactured under strict quality management systems. We provide comprehensive analytical documentation to support research and regulatory submissions. Our standard quality commitment includes HPLC purity verification, mass spectrometry (MS) for identity confirmation, and stringent controls for related substances and residual solvents. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic and easily oxidized nature, the product should be stored under an inert atmosphere (e.g., argon or nitrogen) after opening and allowed to equilibrate to room temperature in a desiccator before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.