Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[2-(2-Methoxy-5-Methylphenyl)Acetyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of novel fluoroquinolone antibiotics and other active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers engaged in the development of next-generation antimicrobial agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Serves as a core scaffold for developing new chemical entities (NCEs) targeting resistant bacterial strains.
• API Synthesis: Used in the final stages or penultimate steps for constructing complex molecules in GMP manufacturing.
• Biochemical Research: Employed in studies investigating structure-activity relationships (SAR) of quinolone-based drugs.
• Contract Manufacturing: Supplied to CMOs for the production of proprietary drug substances under strict quality agreements.
• Reference Standard: High-purity grades are utilized as analytical reference standards for quality control and regulatory submissions.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[2-(2-Methoxy-5-Methylphenyl)Acetyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1051329-89-5
Molecular Formula	C26H26FN3O5
Molecular Weight	479.50 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[2-(2-methoxy-5-methylphenyl)acetyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(2-(2-Methoxy-5-methylphenyl)acetyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK2140944 Intermediate; Gepotidacin Intermediate; Advanced Fluoroquinolone Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(2-(2-methoxy-5-methylphenyl)acetyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development and commercial projects with quality standards suitable for GMP manufacturing and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to ambient light and humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.