Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Methyl-6-Nitrobenzoyl)-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in antimicrobial drug discovery and process chemistry.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a crucial building block in the synthesis of next-generation broad-spectrum antibacterial agents.
• Pharmaceutical R&D: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for clinical trial material and commercial API manufacturing.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.
• Custom Synthesis: A starting material for the custom synthesis of specialized analogs and derivatives for targeted biological testing.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Methyl-6-Nitrobenzoyl)-1-Piperazinyl]-4-Oxo-
CAS No.	1050946-39-8
Molecular Formula	C24H21FN4O6
Molecular Weight	480.45 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(2-methyl-6-nitrobenzoyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(2-Methyl-6-nitrobenzoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; GSK-2140944 Intermediate; Gepotidacin Intermediate; Benzoylpiperazinyl Fluoroquinolone Carboxylic Acid; Antibacterial Quinolone Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.