Description

(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-6-Azido-2-Methylhexanoic Acid is a high-purity, non-natural amino acid derivative featuring a reactive azido group, making it a critical building block for advanced bioconjugation and peptide synthesis. Its primary value lies in enabling click chemistry applications, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC), for the precise and efficient modification of biomolecules. This compound is essential for researchers and manufacturers in pharmaceutical R&D, particularly in the development of antibody-drug conjugates (ADCs), peptide-based therapeutics, and diagnostic probes.

Application

• Peptide Synthesis: Used as a specialized Fmoc-protected amino acid for the solid-phase synthesis of peptides containing azido-functionalized side chains.
• Bioconjugation & ADC Development: Serves as a key linker-payload intermediate for attaching cytotoxic drugs to antibodies or proteins via click chemistry, forming stable triazole linkages.
• Chemical Biology Probes: Enables the site-specific labeling of proteins, enzymes, and other biomolecules with fluorescent dyes, biotin, or other reporter tags for imaging and detection studies.
• Materials Science: Incorporation into polymers or surfaces to create functionalized materials with bio-recognition capabilities for biosensor and diagnostic device development.
• Glycopeptide Mimetics: Used in the synthesis of glycopeptide analogs where the sugar moiety is replaced or mimicked by the azido-functionalized side chain.
• Library Synthesis: A valuable building block for creating diverse combinatorial libraries of azide-containing compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-6-Azido-2-Methylhexanoic Acid
CAS No.	1050501-64-8
Molecular Formula	C25H28N4O4
Molecular Weight	448.52 g/mol
Synonyms	Fmoc-Ahx(N3)-OH; Fmoc-6-azido-L-norleucine; Fmoc-Lys(N3)-OH (isomeric); N-α-Fmoc-N-ε-azido-L-lysine; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-6-azido-2-methylhexanoic acid; Fmoc-Azido-L-lysine; Azido-Fmoc-Lys-OH; Fmoc-L-azidonorleucine
EINECS	Contact for details

Quality Control

Every batch of our (S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-6-Azido-2-Methylhexanoic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and consistency. Our standard specifications are designed to meet the stringent requirements of pharmaceutical research and process development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For short-term use (up to one month), storage at 2-8°C in a desiccator is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.