Description

4'-Trifluoromethoxy-Biphenyl-3-Ylamine Hydrochloride is a high-purity, halogenated aromatic amine hydrochloride salt of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate the unique trifluoromethoxy-biphenyl scaffold into their molecular designs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and material science applications.
• Functional Material Development: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4'-Trifluoromethoxy-Biphenyl-3-Ylamine Hydrochloride
CAS No.	1049736-54-0
Molecular Formula	C13H11F3NO•HCl
Molecular Weight	289.69 g/mol (Free base: 253.23 g/mol)
Synonyms	3-Amino-4'-(trifluoromethoxy)biphenyl hydrochloride; [1,1'-Biphenyl]-3-amine, 4'-(trifluoromethoxy)-, hydrochloride; 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-3-amine hydrochloride; 3-Amino-4'-trifluoromethoxybiphenyl HCl; 4'-Trifluoromethoxybiphenyl-3-ylamine hydrochloride; 3-(4-Trifluoromethoxyphenyl)aniline hydrochloride
EINECS	Contact for details

Quality Control

Our 4'-Trifluoromethoxy-Biphenyl-3-Ylamine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.