Description

2-tert-Butyl-4,6-Dichloropyrimidine is a high-purity, halogenated pyrimidine derivative serving as a critical synthetic intermediate in advanced organic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce the tert-butyl and reactive chlorine functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the pyrimidine core is essential for biological activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological systems and mechanisms.
• Cross-Coupling Reactions: The chlorine atoms provide excellent handles for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form carbon-carbon and carbon-heteroatom bonds.
• Nucleophilic Substitution: The dichloro structure allows for selective, sequential substitution to create a diverse library of 4,6-disubstituted pyrimidine analogs.

Basic Information

Product Name	2-tert-Butyl-4,6-Dichloropyrimidine
CAS No.	1044771-51-8
Molecular Formula	C8H10Cl2N2
Molecular Weight	205.08 g/mol
Synonyms	4,6-Dichloro-2-tert-butylpyrimidine; 2-(1,1-Dimethylethyl)-4,6-dichloropyrimidine; 2-(tert-Butyl)-4,6-dichloropyrimidine; 4,6-Dichloro-2-(tert-butyl)pyrimidine; Pyrimidine, 4,6-dichloro-2-(1,1-dimethylethyl)-; 2-tert-Butyl-4,6-dichloro-pyrimidine
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl-4,6-Dichloropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.