Description

4-Chloro-2-(chloromethyl)-6,7-dimethoxyquinazoline is a high-value, multi-functional quinazoline derivative that serves as a critical synthetic intermediate. This compound is essential for the development of novel pharmaceutical agents, particularly kinase inhibitors and other targeted therapeutics. It is primarily sought after by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of tyrosine kinase inhibitors and other small-molecule drug candidates.
• Chemical Research: Versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Fine Chemical Synthesis: Used in the preparation of complex heterocyclic compounds for agrochemical and material science applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Tool Compound: Utilized in biochemical assays to study enzyme function and cellular signaling pathways.

Basic Information

Item	Details
Product Name	4-Chloro-2-(Chloromethyl)-6,7-Dimethoxyquinazoline
CAS No.	1044768-40-2
Molecular Formula	C₁₁H₁₀Cl₂N₂O₂
Molecular Weight	273.12 g/mol
Synonyms	6,7-Dimethoxy-4-chloro-2-chloromethylquinazoline; 4-Chloro-2-(chloromethyl)-6,7-dimethoxyquinazoline; 2-(Chloromethyl)-4-chloro-6,7-dimethoxyquinazoline; 4-Chloro-6,7-dimethoxy-2-(chloromethyl)quinazoline; Quinazoline, 4-chloro-2-(chloromethyl)-6,7-dimethoxy-; 1044768-40-2; 4-Chloro-2-chloromethyl-6,7-dimethoxyquinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(chloromethyl)-6,7-dimethoxyquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.