Description

4-Chloro-5-Bromo-2-(Cyclopropyl)Pyrimidine is a high-value halogenated pyrimidine derivative, serving as a critical building block in modern organic synthesis. Its unique structure, featuring both chloro and bromo leaving groups on a cyclopropyl-substituted pyrimidine core, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted small-molecule drugs, particularly kinase inhibitors and antiviral agents.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Synthesis Building Block: Enables functionalization and cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to its reactive halogen sites.
• Material Science Research: Potential monomer or precursor for creating specialized polymers and organic electronic materials.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library production.

Basic Information

Product Name	4-Chloro-5-Bromo-2-(Cyclopropyl)Pyrimidine
CAS No.	1044767-90-9
Molecular Formula	C7H6BrClN2
Molecular Weight	233.49 g/mol
Synonyms	2-Cyclopropyl-4-chloro-5-bromopyrimidine; 4-Chloro-5-bromo-2-cyclopropylpyrimidine; 5-Bromo-4-chloro-2-cyclopropylpyrimidine; 4-Chloro-5-bromo-2-(cyclopropyl)pyrimidine; Pyrimidine, 4-chloro-5-bromo-2-cyclopropyl-; 1044767-90-9 (CAS); 4-Chloro-5-bromo-2-cyclopropyl-pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-Bromo-2-(Cyclopropyl)Pyrimidine is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for advanced research and process development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and GC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.