Description

1-Isobutyl-L-Proline is a non-proteinogenic, chiral proline derivative characterized by an isobutyl side chain. This structural modification makes it a valuable synthetic intermediate and building block in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive compounds. Its primary utility lies in medicinal chemistry and peptide research, where it is used to modulate the conformational, pharmacokinetic, and receptor-binding properties of target molecules. Key industries that require this specialized amino acid analog include pharmaceutical R&D, biotechnology, and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and neurological disorders.
• Peptidomimetics & Drug Design: Used to introduce conformational constraints and enhance metabolic stability in the design of novel peptide-based therapeutics and enzyme inhibitors.
• Catalyst & Ligand Synthesis: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Bioconjugation & Probe Development: Employed in the creation of chemical probes and bioconjugates for biochemical research and diagnostic applications.
• Academic & Industrial R&D: A critical reagent for research in organic chemistry, medicinal chemistry, and chemical biology within universities and corporate laboratories.

Basic Information

Product Name	1-Isobutyl-L-Proline
CAS No.	1044637-62-8
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	L-Proline, 1-(2-methylpropyl)-; (S)-1-(2-Methylpropyl)pyrrolidine-2-carboxylic acid; 1-(Isobutyl)-L-proline; (2S)-1-(2-Methylpropyl)pyrrolidine-2-carboxylic acid; 1-Isobutyl-L-proline; 1-(2-Methylpropyl)-L-proline; L-1-Isobutylproline
EINECS	Contact for details

Quality Control

Our 1-Isobutyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to guarantee reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccant or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.