Description

3-Quinolinecarboxylic Acid, 7-[4-(2-Chlorobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone-class antibacterial agents, valued for its precise molecular architecture. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of next-generation antibiotic APIs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel fluoroquinolone antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new antibacterial drug candidates.
• Chemical Synthesis & Process Optimization: Serves as a key substrate for route scouting, scale-up studies, and impurity profiling.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) of bacterial DNA gyrase and topoisomerase IV inhibitors.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxylic Acid, 7-[4-(2-Chlorobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1044146-00-0
Molecular Formula	C24H21ClFN3O3
Molecular Weight	453.90 g/mol
Synonyms	7-[4-(2-Chlorobenzoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-7-[4-(2-chlorobenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Levonadifloxacin Intermediate; (S)-(-)-9-Fluror-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid analog; Benzoic acid, 2-chloro-, 4-(1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate)piperazinyl deriv.; Fluoroquinolone intermediate 1044146-00-0.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and impurity profile, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.