Description

4-Fluoro-2-Nitrobenzyl Alcohol is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a nitro and a benzyl alcohol group on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors. It serves as a key precursor in the development of active pharmaceutical ingredients (APIs) and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Research: Used in the development and production of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for fluorinated aromatic components used in electronic display technologies.
• Functional Polymer Modification: Employed to introduce fluorinated nitrobenzyl groups into polymer chains, altering physical and chemical properties for specialized applications.
• Cross-Coupling Reactions: The reactive benzyl alcohol and halogenated aromatic system make it suitable for palladium-catalyzed coupling reactions to create complex biaryl structures.
• Protecting Group Chemistry: Can be utilized in the development of novel photolabile or chemically cleavable protecting groups for sensitive functional groups in multi-step syntheses.

Basic Information

Product Name	4-Fluoro-2-Nitrobenzyl Alcohol
CAS No.	1043416-40-5
Molecular Formula	C7H6FNO3
Molecular Weight	171.13 g/mol
Synonyms	2-Nitro-4-fluorobenzyl alcohol; (4-Fluoro-2-nitrophenyl)methanol; 4-Fluoro-2-nitrobenzenemethanol; 1-(Hydroxymethyl)-4-fluoro-2-nitrobenzene; 4-Fluoro-2-nitrobenzylalcohol; α-Hydroxy-4-fluoro-2-nitrotoluene; Benzenemethanol, 4-fluoro-2-nitro-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitrobenzyl Alcohol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the container has been opened.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.