Description

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-Eddnp is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critically important for biochemical research and pharmaceutical development, particularly in the study of protease activity and enzyme kinetics. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in drug discovery and biomarker research.

Application

• Protease Activity Assays: As a specialized substrate for measuring the activity of specific caspases and other proteolytic enzymes in cell biology and apoptosis research.
• High-Throughput Screening (HTS): Used in automated drug discovery platforms to identify and characterize novel enzyme inhibitors or activators.
• Diagnostic Development: Serves as a key component in the development of in vitro diagnostic (IVD) tests for detecting enzymatic biomarkers associated with diseases.
• Biochemical Research: A vital tool for kinetic studies, enzyme mechanism elucidation, and determining kinetic parameters (Km, Vmax) in purified enzyme systems.
• Pharmaceutical QC: Employed in quality control laboratories for potency testing of biopharmaceuticals that target specific protease pathways.

Basic Information

Product Name	Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-Eddnp
CAS No.	1042405-14-0
Molecular Formula	C₆₀H₉₃N₂₁O₁₈
Molecular Weight	1412.5 g/mol
Synonyms	Abz-VADNva-AR-DR-Q-EDDnp; Caspase-3 Substrate (Fluorogenic); (Abz)-Val-Ala-Asp-(Nva)-Arg-Asp-Arg-Gln-(EDDnp); Fluorogenic Peptide Substrate for Caspase-3; Ac-VADNva-ARDR-Q-EDDnp; Caspase-3/7 Fluorogenic Substrate; EDDnp Peptide Substrate; Caspase Activity Assay Substrate
EINECS	Contact for details

Quality Control

Our Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-Eddnp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.