Description

2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine-7-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex heterocyclic molecules, particularly kinase inhibitors and other targeted therapeutics. It is essential for research institutions, CROs, and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, especially in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for targeted cancer therapies.
• Kinase Inhibitor Development: Core scaffold for the research and production of protein kinase inhibitors, a major class of oncology drugs.
• Antiviral Drug Synthesis: Used in the construction of nucleoside/nucleotide analogs and other heterocyclic compounds with potential antiviral activity.
• Chemical Biology & Proteomics: Serves as a versatile handle for creating chemical probes to study enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical R&D pipelines.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and novel synthetic methodology development.

Basic Information

Item	Details
Product Name	2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine-7-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1038588-24-7
Molecular Formula	C13H13Cl2N3O2
Molecular Weight	314.17 g/mol
Synonyms	tert-Butyl 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate; 2,4-Dichloro-7-((tert-butoxy)carbonyl)-7H-pyrrolo[2,3-d]pyrimidine; 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester; Boc-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine; 2,4-Dichloro-7-Boc-7H-pyrrolo[2,3-d]pyrimidine; 1038588-24-7; 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine-7-Carboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical R&D and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity and identity confirmation (NMR, MS). We provide full traceability and detailed Certificates of Analysis (COA) upon request, supporting compliance with internal quality standards and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.