Description

(Asp28)-Glucagon (1-29) (Human, Rat, Porcine) is a synthetic peptide analog of the glucagon hormone, modified at position 28 with an aspartic acid residue. This engineered sequence is critical for advanced research into metabolic pathways, receptor binding studies, and the development of novel therapeutic agents. It is an essential tool for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on diabetes, obesity, and metabolic disease research. The compound is supplied under stringent quality control to ensure batch-to-batch consistency for reliable experimental results.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of glucagon receptor (GCGR) signaling and activation mechanisms.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of next-generation peptide-based therapeutics for metabolic disorders.
• In Vitro & In Vivo Studies: Employed in cell-based assays and animal models (human, rat, porcine) to investigate glucose metabolism, glycogenolysis, and the physiological effects of glucagon analogs.
• Analytical Method Development: Utilized as a calibration standard in HPLC, LC-MS, and other chromatographic techniques for peptide quantification and purity analysis.
• Structure-Activity Relationship (SAR) Studies: The specific Asp28 modification makes it a valuable probe for understanding the impact of amino acid substitutions on peptide stability, potency, and selectivity.

Basic Information

Product Name	(Asp28)-Glucagon (1-29) (Human, Rat, Porcine)
CAS No.	1037751-81-7
Molecular Formula	C153H225N43O49S
Molecular Weight	3484.7 g/mol
Synonyms	Asp28-Glucagon (1-29); [Asp28]Glucagon; Glucagon (1-29), Asp28-; H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asp-Thr-NH2; Glucagon analog (Asp28); Synthetic glucagon fragment 1-29 (Asp28)
EINECS	Contact for details

Quality Control

Every batch of (Asp28)-Glucagon (1-29) is manufactured and tested under a quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide synthesis. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, identity, and content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under dry, controlled conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (Content)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.