Description

5-Bromo-4-Chloro-7-((2-(Trimethylsilyl)Ethoxy)Methyl)-7H-Pyrrolo[2,3-D]Pyrimidine is a high-value, functionalized pyrrolopyrimidine derivative, serving as a critical advanced pharmaceutical intermediate in modern drug discovery and development. Its unique halogenated and silyl-protected structure makes it an essential building block for the synthesis of complex molecules targeting various therapeutic areas. This compound is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the production of nucleoside analogs and kinase inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog drugs and kinase inhibitors for oncology and antiviral therapies.
• Antiviral Drug Development: Used in research and production of compounds targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a core scaffold for developing small molecule inhibitors targeting specific protein kinases involved in cancer cell signaling.
• Chemical Biology & Proteomics: Employed as a tagged or functionalized probe for studying enzyme-substrate interactions and cellular processes.
• Agrochemical Synthesis: Potential intermediate for creating novel, high-performance crop protection agents with specific modes of action.
• Custom Synthesis & Scale-Up: Supplied to fine chemical manufacturers for custom synthesis projects from gram to kilogram scale under cGMP conditions.

Basic Information

Product Name	5-Bromo-4-Chloro-7-((2-(Trimethylsilyl)Ethoxy)Methyl)-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	1034769-73-7
Molecular Formula	C12H17BrClN3OSi
Molecular Weight	378.71 g/mol
Synonyms	5-Bromo-4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-7-[[2-(trimethylsilyl)ethoxy]methyl]-; 5-Bromo-4-chloro-7-(2-trimethylsilylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine; 5-Br-4-Cl-7-SEM-pyrrolo[2,3-d]pyrimidine; 5-Bromo-4-chloro-7-SEM-pyrrolopyrimidine; 1034769-73-7; BrCl-SEM-Pyrrolopyrimidine; Pyrrolo[2,3-d]pyrimidine SEM-protected intermediate
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-4-Chloro-7-((2-(Trimethylsilyl)Ethoxy)Methyl)-7H-Pyrrolo[2,3-D]Pyrimidine adheres to stringent quality protocols suitable for pharmaceutical R&D and cGMP manufacturing. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, NMR and MS confirmation of structure, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.