Description

cis-2-Amino-Cycloheptanecarboxylic Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative, specifically engineered as a critical building block for advanced pharmaceutical and biochemical research. Its constrained seven-membered ring structure offers unique conformational properties, making it invaluable for modulating peptide stability and biological activity. This compound is essential for medicinal chemists and researchers in drug discovery, particularly for developing novel peptide-based therapeutics, enzyme inhibitors, and as a chiral synthon in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptidomimetics Research: Used to introduce conformational constraints into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Enzyme Inhibitor Development: Serves as a core structure for designing potent and selective inhibitors of proteases and other enzymes.
• Asymmetric Synthesis: Acts as a valuable chiral auxiliary or starting material in stereoselective organic synthesis.
• Biochemical Tool Compound: Employed in structural biology and mechanistic studies to probe protein-ligand interactions.
• Combinatorial Chemistry: Integrated into libraries for high-throughput screening to identify new lead compounds.

Basic Information

Product Name	cis-2-Amino-Cycloheptanecarboxylic Acid Hydrochloride
CAS No.	1033756-97-6
Molecular Formula	C8H15NO2 • HCl
Molecular Weight	193.67 g/mol (Free base: 157.21 g/mol)
Synonyms	(1R,2S)-2-Aminocycloheptanecarboxylic acid hydrochloride; (1R,2S)-2-Amino-cycloheptane-1-carboxylic acid hydrochloride; cis-2-Aminocycloheptanecarboxylic acid HCl; cis-2-Amino-cycloheptane-1-carboxylic acid hydrochloride; 2-Aminocycloheptanecarboxylic acid hydrochloride (cis isomer); Cycloheptane amino acid derivative HCl; 1-Carboxy-2-aminocycloheptane hydrochloride
EINECS	Contact for details

Quality Control

Every batch of cis-2-Amino-Cycloheptanecarboxylic Acid Hydrochloride is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for pharmaceutical research and development. Comprehensive analytical testing, including chiral purity verification, is performed. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (cis isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.