Description

Fmoc-D-Propargylglycine CAS NO 1033622-38-6 is a high-purity, non-natural amino acid derivative featuring a propargyl side chain protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block for the synthesis of peptide-based drugs and bioconjugates, enabling site-specific modifications via click chemistry. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in the development of novel therapeutics, diagnostic probes, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing alkyne-functionalized residues.
• Bioconjugation & Labeling: Enables the site-specific incorporation of an alkyne handle into peptides for subsequent conjugation with azide-bearing fluorophores, drugs, or polymers via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptidomimetic Drug Discovery: Used to introduce rigid, linear alkyne spacers into peptide backbones to modulate structure-activity relationships and improve metabolic stability.
• Chemical Biology Probes: Essential for creating activity-based probes and photoaffinity labels to study enzyme function and protein-protein interactions.
• Material Science: Serves as a monomer for the synthesis of functionalized polymers and biomaterials with tailored surface properties.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the development of novel linker technologies for attaching cytotoxic payloads to antibodies.

Basic Information

Product Name	Fmoc-D-Propargylglycine
CAS No.	1033622-38-6
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-D-2-amino-5-hexynoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-amino-5-hexynoic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hex-5-ynoic acid; Fmoc-D-Hag-OH; Fmoc-D-propargylglycine; D-Fmoc-propargylglycine; Fmoc-D-Pra-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Propargylglycine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing HPLC purity, chiral purity, and other critical parameters. Our quality commitment supports applications requiring compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.