Description

[1-(5-Fluoro-Pyrimidin-2-Yl)-Piperidin-4-Yl]-Methanol is a high-purity, advanced pharmaceutical intermediate with the CAS number 1032825-49-2. This compound is a critical building block in modern medicinal chemistry, valued for its piperidine-pyrimidine core which is integral to modulating biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Used in constructing candidate molecules targeting various kinase enzymes for cancer therapy.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Drug Development: Employed in the synthesis of compounds for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized to create tool compounds for investigating specific biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	[1-(5-Fluoro-Pyrimidin-2-Yl)-Piperidin-4-Yl]-Methanol
CAS No.	1032825-49-2
Molecular Formula	C10H12FN3O
Molecular Weight	209.22 g/mol
Synonyms	4-(Hydroxymethyl)-1-(5-fluoropyrimidin-2-yl)piperidine; 1-(5-Fluoropyrimidin-2-yl)piperidine-4-methanol; (1-(5-Fluoropyrimidin-2-yl)piperidin-4-yl)methanol; 1032825-49-2; 5-Fluoro-2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our [1-(5-Fluoro-Pyrimidin-2-Yl)-Piperidin-4-Yl]-Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and industry best practices for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.