Description

3-(2-Chloropyrimidin-4-Yl)-1-Methylindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted small-molecule drugs.
• Kinase Inhibitor Development: Used in research and production of protein kinase inhibitors, a major class of oncology therapeutics.
• Chemical Biology Research: Employed as a molecular probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Potential application as an intermediate in the development of advanced crop protection agents.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development projects.
• Academic Research: Utilized in university and institutional labs for novel heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	3-(2-Chloropyrimidin-4-Yl)-1-Methylindole
CAS No.	1032452-86-0
Molecular Formula	C13H10ClN3
Molecular Weight	243.69 g/mol
Synonyms	1-Methyl-3-(2-chloropyrimidin-4-yl)-1H-indole; 3-(2-Chloro-4-pyrimidinyl)-1-methyl-1H-indole; 1-Methyl-3-(2-chloro-4-pyrimidinyl)indole; 4-(1-Methyl-1H-indol-3-yl)-2-chloropyrimidine; 2-Chloro-4-(1-methyl-1H-indol-3-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our production of 3-(2-Chloropyrimidin-4-Yl)-1-Methylindole adheres to stringent quality management protocols. The material is manufactured and tested to meet exacting standards suitable for pharmaceutical R&D and GMP-grade synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.