Description

(R)-1,1,1-Trifluoro-3-Methyl-2-Butylamine CAS NO 1032181-63-7 is a high-value, chiral amine building block characterized by its trifluoromethyl group and stereogenic center. This compound is critical for introducing fluorine atoms and specific three-dimensional structure into target molecules, which can dramatically alter their physicochemical and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in areas like protease inhibitors, kinase inhibitors, and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine moiety enhances lipophilicity, metabolic stability, and membrane permeability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity in complex chemical reactions.
• Material Science Research: Employed in the development of specialty polymers and advanced materials where fluorinated compounds impart unique properties like chemical resistance and low surface energy.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on exploring the effects of fluorination in medicinal and synthetic chemistry.

Basic Information

Product Name	(R)-1,1,1-Trifluoro-3-Methyl-2-Butylamine
CAS No.	1032181-63-7
Molecular Formula	C5H10F3N
Molecular Weight	141.14 g/mol
Synonyms	(R)-1,1,1-Trifluoro-3-methylbutan-2-amine; (2R)-1,1,1-Trifluoro-3-methyl-2-butanamine; (R)-TFMBA; (R)-α-Methyl-3,3,3-trifluoroisopropylamine; (R)-3-Methyl-1,1,1-trifluoro-2-butanamine; (R)-1,1,1-Trifluoro-3-methyl-2-butylamine; (R)-3,3,3-Trifluoro-2-amino-2-methylbutane
EINECS	Contact for details

Quality Control

Our (R)-1,1,1-Trifluoro-3-Methyl-2-Butylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.