Description

1-(2-Fluoro-4-Methylphenyl)-1H-Pyrrole-2,5-Dione is a high-purity, fluorinated maleimide derivative, a key structural motif in advanced organic synthesis. This compound is valued for its role as a versatile building block in the development of pharmaceuticals and agrochemicals, where its unique fluorinated aromatic system can modulate biological activity and physicochemical properties. It is essential for research chemists and process development scientists in fine chemical, pharmaceutical, and agrochemical R&D seeking to introduce specific fluorinated heterocyclic scaffolds into novel molecular entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a key building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Material Science Research: Used in the development of specialty polymers and advanced organic electronic materials due to its electron-deficient maleimide core.
• Bioconjugation & Probe Development: Acts as a reactive handle for labeling biomolecules (proteins, peptides) in biochemical research and diagnostic assay development.
• Chemical Biology Tool: Employed in fragment-based drug discovery and as a scaffold for creating chemical probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	1-(2-Fluoro-4-Methylphenyl)-1H-Pyrrole-2,5-Dione
CAS No.	1030420-86-0
Molecular Formula	C11H8FNO2
Molecular Weight	205.19 g/mol
Synonyms	1-(2-Fluoro-4-methylphenyl)-1H-pyrrole-2,5-dione; 2-Fluoro-4-methyl-N-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzamide (tautomeric form); 1-(2-Fluoro-4-methylphenyl)maleimide; N-(2-Fluoro-4-methylphenyl)maleimide; Fluorinated maleimide derivative; 2,5-Pyrroledione, 1-(2-fluoro-4-methylphenyl)-; 1030420-86-0; FC-IMP-103
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-4-Methylphenyl)-1H-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.