Description

1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(2-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a critical building block for the synthesis of novel fluoroquinolone antibiotics, enabling the development of next-generation antimicrobial agents. This compound is essential for research institutions and pharmaceutical manufacturers engaged in API development, particularly those targeting drug-resistant bacterial infections.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key intermediate in the production of advanced fluoroquinolone antibiotic compounds.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of new antibacterial drug candidates.
• Process Chemistry & Scale-Up: Serves as a critical starting material for process optimization and pilot-scale manufacturing of APIs.
• Reference Standard: Employed as an analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(2-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
CAS No.	1029364-65-5
Molecular Formula	C19H21FN4O4
Molecular Weight	388.39 g/mol
Synonyms	7-(2-Methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(2-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Fluoroquinolone Intermediate; Quinolone Carboxylic Acid Derivative; Antibacterial Intermediate
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development and commercial projects requiring material that meets ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.