Description

4-Pyrimidinecarboxylic Acid, 2-Chloro-6-(Trifluoromethyl)-, Ethyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique structure, featuring both chloro and trifluoromethyl substituents on the pyrimidine core, provides critical reactivity and physicochemical properties for developing novel active molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Serves as a crucial building block for creating new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the development of advanced organic materials, such as ligands for catalysts or components for organic electronic devices.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in biochemical research to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	4-Pyrimidinecarboxylic Acid, 2-Chloro-6-(Trifluoromethyl)-, Ethyl Ester
CAS No.	1027059-34-2
Molecular Formula	C8H6ClF3N2O2
Molecular Weight	254.59 g/mol
Synonyms	Ethyl 2-Chloro-6-(trifluoromethyl)pyrimidine-4-carboxylate; 2-Chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid Ethyl Ester; 4-Carbethoxy-2-chloro-6-trifluoromethylpyrimidine; 2-Chloro-4-(ethoxycarbonyl)-6-(trifluoromethyl)pyrimidine; 1027059-34-2; Ethyl 2-chloro-6-(trifluoromethyl)-4-pyrimidinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinecarboxylic Acid, 2-Chloro-6-(Trifluoromethyl)-, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.