Description

1-Methyl-1H-Pyrazole-5-Sulphonyl Chloride is a versatile and highly reactive sulphonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonylation reagent, facilitating the introduction of the sulfonyl functional group to construct complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that incorporate sulfonylurea or sulfonamide moieties.
• Functional Material Precursor: Employed in the research and production of specialty polymers, dyes, and liquid crystals.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling.
• Cross-Coupling Reactions: Serves as an electrophilic partner in metal-catalyzed cross-coupling reactions to form carbon-sulfur bonds.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Methyl-1H-Pyrazole-5-Sulphonyl Chloride
CAS No.	1020721-61-2
Molecular Formula	C4H5ClN2O2S
Molecular Weight	180.61 g/mol
Synonyms	1-Methyl-1H-pyrazole-5-sulfonyl chloride; 1-Methylpyrazole-5-sulfonyl chloride; 5-(Chlorosulfonyl)-1-methyl-1H-pyrazole; 1-Methyl-5-pyrazolesulfonyl chloride; 1-Methyl-1H-pyrazole-5-sulfonchlorid; 1-Methylpyrazole-5-sulphonyl chloride; Pyrazole-5-sulfonyl chloride, 1-methyl-
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Pyrazole-5-Sulphonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended long-term storage temperature is 2-8°C. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.