Description

(S)-7-Fluorochroman-4-Amine is a chiral, fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and high-value pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique stereochemistry and fluorine atom into new molecular entities.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential central nervous system (CNS) agents, serotonin receptor modulators, and other bioactive molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the chroman scaffold and fluorine substitution can enhance biological activity and stability.
• Asymmetric Synthesis: Employed as a chiral amine source or template in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry: A crucial scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry: Serves as a model compound for studying the effects of fluorine substitution on the properties of chroman-based systems.
• Fine Chemical Synthesis: Used in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	(S)-7-Fluorochroman-4-Amine
CAS No.	1018978-91-0
Molecular Formula	C9H10FNO
Molecular Weight	167.18 g/mol
Synonyms	(4S)-7-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-7-Fluoro-3,4-dihydro-2H-chromen-4-amine; (S)-7-Fluorochroman-4-ylamine; 7-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine, (4S)-; (S)-4-Amino-7-fluorochroman; 4-Amino-7-fluorochroman (S-enantiomer); (S)-enantiomer of 7-Fluorochroman-4-amine
EINECS	Contact for details

Quality Control

Our (S)-7-Fluorochroman-4-Amine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.