Description

1-(6-Chloropyrimidin-4-Yl)-3-Methyl-1H-Pyrazol-5-Amine is a high-purity heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules with targeted biological activity, offering a versatile scaffold for medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the discovery and production of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its pyrimidine-pyrazole hybrid structure for bioactivity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Material Science Research: Investigated as a building block for organic electronic materials and metal-organic frameworks (MOFs) due to its nitrogen-rich, chelating structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-(6-Chloropyrimidin-4-Yl)-3-Methyl-1H-Pyrazol-5-Amine
CAS No.	1018473-22-7
Molecular Formula	C8H8ClN5
Molecular Weight	209.64 g/mol
Synonyms	3-Methyl-1-(6-chloropyrimidin-4-yl)-1H-pyrazol-5-amine; 1H-Pyrazol-5-amine, 1-(6-chloro-4-pyrimidinyl)-3-methyl-; 5-Amino-3-methyl-1-(6-chloropyrimidin-4-yl)pyrazole; 1-(6-Chloro-4-pyrimidinyl)-3-methyl-1H-pyrazol-5-amine; 6-Chloro-4-(5-amino-3-methyl-1H-pyrazol-1-yl)pyrimidine; CAS 1018473-22-7
EINECS	Contact for details

Quality Control

Our 1-(6-Chloropyrimidin-4-Yl)-3-Methyl-1H-Pyrazol-5-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.