Description

4-Chloro-3-Fluoro-2-Iodoaniline is a high-purity, multi-halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an exceptionally valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the halogen atoms contribute to biological activity and stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as charge-transport layers or ligands for metal-organic frameworks (MOFs), due to its electron-withdrawing halogen groups.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for designing chemical probes, affinity tags, or cross-linking agents used in studying protein function and interactions.
• Dye & Pigment Intermediate: Serves as a starting material for synthesizing specialized azo dyes and pigments with specific color fastness and spectral properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects requiring precise halogenated aromatic amines.

Basic Information

Product Name	4-Chloro-3-Fluoro-2-Iodoaniline
CAS No.	1018450-37-7
Molecular Formula	C6H4ClFIN
Molecular Weight	271.46 g/mol
Synonyms	2-Iodo-4-chloro-3-fluoroaniline; 4-Chloro-3-fluoro-2-iodobenzenamine; Benzenamine, 4-chloro-3-fluoro-2-iodo-; 2-Amino-1-chloro-6-fluoro-3-iodobenzene; 3-Fluoro-4-chloro-2-iodoaniline; 4-Chloro-3-fluoroaniline, 2-iodo-; 1018450-37-7 (CAS); 4-Cl-3-F-2-I-aniline
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoro-2-Iodoaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee consistent quality and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.