Description

(4S)-1-Boc-4-(Fmoc-Amino)-D-Proline CAS NO 1018332-23-4 is a high-purity, dual-protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and orthogonal deprotection strategies in complex molecule assembly. It is an essential building block for pharmaceutical R&D, particularly in the development of peptide-based therapeutics, APIs, and diagnostic agents where the integrity of the D-proline configuration is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of D-proline residues.
• Pharmaceutical Intermediate: Building block for the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs) and novel drug candidates.
• Peptidomimetic Research: Used in the design and synthesis of non-natural peptide analogs with enhanced stability and bioavailability.
• Combinatorial Chemistry: Valuable scaffold for generating diverse chemical libraries in drug discovery platforms.
• Bioconjugation: Serves as a linker or modified amino acid in the preparation of peptide-protein or peptide-small molecule conjugates.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(4S)-1-Boc-4-(Fmoc-Amino)-D-Proline
CAS No.	1018332-23-4
Molecular Formula	C26H30N2O6
Molecular Weight	466.53 g/mol
Synonyms	1-Boc-4-[(9-fluorenylmethoxycarbonyl)amino]-D-proline; Fmoc-NH-D-Pro(4)-OH, Boc protected; (4R)-1-(tert-Butoxycarbonyl)-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-D-proline; tert-Butyl (4R)-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-D-prolinate; Boc-D-Pro(4-NHFmoc)-OH; D-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (4R)-; Fmoc-4-amino-D-proline(Boc)-OH
EINECS	Contact for details

Quality Control

Every batch of (4S)-1-Boc-4-(Fmoc-Amino)-D-Proline is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.