Description

5-(Difluoromethyl)[1,2,4]Triazolo[1,5-A]Pyrimidin-7(4H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its fused heterocyclic structure containing both triazole and pyrimidine rings. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in agrochemical and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector seeking to develop new compounds with enhanced biological activity.

Application

This specialized intermediate serves critical functions in advanced chemical synthesis across several high-value industries.

• Agrochemical Intermediate: A key precursor in the research and development of new-generation fungicides and herbicides.
• Pharmaceutical Intermediate: Used in the synthesis of potential drug candidates, especially those targeting enzymes or receptors where the triazolopyrimidine scaffold is active.
• Chemical Research & Development: Serves as a versatile building block for constructing complex heterocyclic libraries for high-throughput screening in drug discovery.
• Material Science Research: Investigated for the development of novel organic electronic materials or ligands for catalytic systems.

Basic Information

Product Name	5-(Difluoromethyl)[1,2,4]Triazolo[1,5-A]Pyrimidin-7(4H)-One
CAS No.	1018125-45-5
Molecular Formula	C7H5F2N5O
Molecular Weight	213.15 g/mol
Synonyms	5-(Difluoromethyl)-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one; 5-(Difluoromethyl)-7H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one; 5-(Difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one; [1,2,4]Triazolo[1,5-a]pyrimidin-7(4H)-one, 5-(difluoromethyl)-; 1018125-45-5; DFMTPO (abbreviation)
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)[1,2,4]Triazolo[1,5-A]Pyrimidin-7(4H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical and agrochemical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.