Description

7-(Difluoromethyl)-5-(4-Methoxyphenyl)[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylic Acid CAS NO 1018053-78-5 is a high-purity, advanced pharmaceutical intermediate belonging to the triazolopyrimidine class of heterocyclic compounds. This specialized chemical is critical for research and development in modern agrochemical and pharmaceutical synthesis, where its unique difluoromethyl and carboxylic acid functionalities enable precise molecular modifications. It is primarily sought by R&D chemists and process development scientists in the agrochemical and pharmaceutical industries for creating novel active ingredients with enhanced properties.

Application

• Key Intermediate in Agrochemical Synthesis: Serves as a crucial building block for developing next-generation fungicides and herbicides, leveraging the triazolopyrimidine core for targeted biological activity.
• Pharmaceutical Research & Development: Used in the synthesis of potential drug candidates, particularly in areas requiring fluorinated heterocycles for improved metabolic stability and bioavailability.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): The carboxylic acid group allows for conjugation, making it a valuable linker or component in the design of bifunctional molecules for targeted protein degradation.
• Material Science Research: Investigated for the development of novel organic electronic materials or metal-organic frameworks (MOFs) due to its rigid, planar structure and multiple coordination sites.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific compounds and scaled-up processes.

Basic Information

Item	Detail
Product Name	7-(Difluoromethyl)-5-(4-Methoxyphenyl)[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylic Acid
CAS No.	1018053-78-5
Molecular Formula	C15H10F2N4O3
Molecular Weight	332.26 g/mol
Synonyms	7-(Difluoromethyl)-5-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid; 5-(4-Methoxyphenyl)-7-(difluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic Acid; [1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxylic acid, 7-(difluoromethyl)-5-(4-methoxyphenyl)-; 1018053-78-5; 7-Difluoromethyl-5-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 7-(Difluoromethyl)-5-(4-Methoxyphenyl)[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.