Description

3-Fluoro-4-(Trifluoromethoxy)Aniline is a high-value fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, imparts significant electronic and steric properties essential for developing novel active compounds. This intermediate is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for creating next-generation products with enhanced efficacy and stability. Its reliable synthesis and consistent quality are paramount for successful scale-up and regulatory approval processes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity, metabolic stability, and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Functional Material Development: Intermediate for creating specialty polymers, dyes, and organic electronic materials that require specific fluorination patterns.
• Cross-Coupling Reactions: The aniline group makes it a suitable substrate for Buchwald-Hartwig amination and other palladium-catalyzed cross-coupling reactions to construct complex nitrogen-containing heterocycles.

Basic Information

Item	Details
Product Name	3-Fluoro-4-(Trifluoromethoxy)Aniline
CAS No.	1017779-69-9
Molecular Formula	C7H5F4NO
Molecular Weight	195.12 g/mol
Synonyms	3-Fluoro-4-(trifluoromethoxy)benzenamine; 4-Amino-2-fluoro-1-(trifluoromethoxy)benzene; 2-Fluoro-4-amino-1-(trifluoromethoxy)benzene; 3-Fluoro-4-trifluoromethoxyaniline; 3-Fluoro-4-(trifluoromethoxy)phenylamine; Benzenamine, 3-fluoro-4-(trifluoromethoxy)-; 3-Fluoro-4-(trifluoromethoxy)aniline (primary synonym)
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-(Trifluoromethoxy)Aniline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by HPLC), identity confirmation, and impurity profiles. Our quality commitment supports compliance in cGMP and ISO 9001 environments for pharmaceutical and industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.