Description

2-(Difluoromethoxy)-5-Fluorobenzylamine is a high-purity fluorinated benzylamine derivative, a critical building block in advanced organic synthesis. Its value lies in its unique difluoromethoxy and fluoro substituents, which are strategically incorporated to modulate the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A versatile synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing material properties like chemical resistance and thermal stability.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.
• Fluorinated Probe & Dye Synthesis: Used in the creation of specialized biochemical tools and imaging agents for diagnostic and research applications.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Fluorobenzylamine
CAS No.	1017779-46-2
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	5-Fluoro-2-(difluoromethoxy)benzylamine; (5-Fluoro-2-(difluoromethoxy)phenyl)methanamine; 2-(Difluoromethoxy)-5-fluorobenzenemethanamine; α-Amino-5-fluoro-2-(difluoromethoxy)toluene; 1017779-46-2; 5-Fluoro-2-difluoromethoxybenzylamine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-5-Fluorobenzylamine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and reliable supply for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.