Description

4-Ethoxy-3,5-difluorophenol is a versatile fluorinated phenolic intermediate of significant interest in advanced organic synthesis. Its molecular structure, featuring both ethoxy and fluorine substituents, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluorophenol moiety can enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated mesogens used in the production of advanced display technologies.
• Polymer Chemistry: Acts as a monomer or chain modifier in the synthesis of specialty polymers, including polyarylates and epoxy resins, to improve thermal and chemical resistance.
• Organic Electronic Materials: Utilized in the research and development of organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Chemical Research: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Ethoxy-3,5-difluorophenol
CAS No.	1017779-45-1
Molecular Formula	C8H8F2O2
Molecular Weight	174.15 g/mol
Synonyms	3,5-Difluoro-4-ethoxyphenol; 4-Ethoxy-3,5-difluorophenol; Phenol, 4-ethoxy-3,5-difluoro-; 1-Ethoxy-2,6-difluoro-4-hydroxybenzene; 2,6-Difluoro-4-ethoxyphenol; 4-Hydroxy-2,6-difluoroanisole; 4-Ethoxy-3,5-difluorophenol (major)
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-3,5-difluorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C/59-77°F) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.