Description

4-Ethoxy-3,5-Difluorobenzylalcohol is a high-value fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of fluorinated drug candidates, potentially for central nervous system (CNS) agents, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluoroethoxy moiety can enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in display technologies, where specific fluorine substitution patterns are critical for tuning electro-optical properties.
• Organic Electronic Materials: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials for OLEDs and other electronic devices.
• Advanced Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with tailored surface properties and chemical resistance.
• Cross-Coupling Reactions: The benzyl alcohol group can be transformed into various functionalities, making it a valuable substrate in Pd-catalyzed and other metal-mediated coupling reactions.

Basic Information

Item	Detail
Product Name	4-Ethoxy-3,5-Difluorobenzylalcohol
CAS No.	1017779-35-9
Molecular Formula	C9H10F2O2
Molecular Weight	188.17 g/mol
Synonyms	1-(4-Ethoxy-3,5-difluorophenyl)methanol; (4-Ethoxy-3,5-difluorophenyl)methanol; 3,5-Difluoro-4-ethoxybenzyl alcohol; 4-Ethoxy-3,5-difluorobenzenemethanol; α-Hydroxymethyl-4-ethoxy-3,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our production of 4-Ethoxy-3,5-Difluorobenzylalcohol adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality system is designed to support cGMP and ISO standards for demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation and absorption of water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.