Description

3-Chloro-4-Ethoxy-5-Fluorobenzylbromide is a high-purity, multi-functional halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring chloro, ethoxy, fluoro, and bromomethyl substituents, makes it an exceptionally versatile intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and ether groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating specialized aromatic cores in electronic and optoelectronic materials.
• Cross-Coupling Reactions: The benzyl bromide moiety is reactive in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Functional Material Research: Employed in the development of polymers, ligands for catalysis, and other specialty chemicals requiring a tailored aromatic scaffold.

Basic Information

Product Name	3-Chloro-4-Ethoxy-5-Fluorobenzylbromide
CAS No.	1017778-91-4
Molecular Formula	C9H9BrClFO
Molecular Weight	267.52 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-4-ethoxy-5-fluorobenzene; 3-Chloro-4-ethoxy-5-fluorobenzyl bromide; (3-Chloro-4-ethoxy-5-fluorophenyl)methyl bromide; α-Bromo-3-chloro-4-ethoxy-5-fluorotoluene; Benzene, 1-(bromomethyl)-3-chloro-4-ethoxy-5-fluoro-; 5-Fluoro-3-chloro-4-ethoxybenzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Ethoxy-5-Fluorobenzylbromide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.