Description

3-Chloro-5-(Trifluoromethoxy)Phenol is a high-purity fluorinated phenolic compound, serving as a critical advanced intermediate in modern organic synthesis. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a valuable building block for introducing specific steric and electronic properties into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, contributing to the molecular framework of liquid crystals and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as chemical resistance, thermal stability, or altered surface properties.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in medicinal chemistry and material science for structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Phenol
CAS No.	1017778-52-7
Molecular Formula	C7H4ClF3O2
Molecular Weight	212.55 g/mol
Synonyms	3-Chloro-5-(trifluoromethoxy)phenol; Phenol, 3-chloro-5-(trifluoromethoxy)-; 1-Chloro-3-hydroxy-5-(trifluoromethoxy)benzene; 5-Chloro-3-(trifluoromethoxy)phenol; 3-Chloro-α,α,α-trifluoro-5-methoxyphenol
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.