Description

3-Ethoxy-2,4-Difluorobenzyl Bromide is a high-purity, multi-functional organic building block characterized by its benzyl bromide core flanked by ethoxy and fluorine substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in fluorinated compound libraries.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the difluoroethoxy moiety imparts specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic cores used in electronic display technologies.
• Cross-Coupling Reactions: The benzyl bromide group makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Functional Polymer Monomer: Can be incorporated into polymer backbones to modify thermal stability, solubility, and optical properties.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorinated aromatic chemistries.

Basic Information

Product Name	3-Ethoxy-2,4-Difluorobenzyl Bromide
CAS No.	1017778-22-1
Molecular Formula	C9H9BrF2O
Molecular Weight	251.07 g/mol
Synonyms	1-(Bromomethyl)-3-ethoxy-2,4-difluorobenzene; 2,4-Difluoro-3-ethoxybenzyl Bromide; (3-ethoxy-2,4-difluorophenyl)methyl bromide; Benzene, 1-(bromomethyl)-3-ethoxy-2,4-difluoro-; 3-Ethoxy-2,4-difluorobenzylbromide; 2,4-Difluoro-3-ethoxybenzylbromide; α-Bromo-3-ethoxy-2,4-difluorotoluene
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-2,4-Difluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.