Description

6-Chloro-2-Fluoro-3-Methoxyaniline is a high-purity, multi-functional aromatic amine building block of significant commercial importance. Its unique halogenated and methoxylated structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and specialty agrochemicals. This product is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Serves as a versatile precursor in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aniline core.
• Liquid Crystal & OLED Material Precursor: Used in the synthesis of specialized aromatic compounds for electronic display and semiconductor applications.
• Dye & Pigment Intermediate: Functions as a building block for creating high-performance, halogenated dyes and organic pigments.
• Cross-Coupling Reactions: An ideal substrate for Buchwald-Hartwig amination, Suzuki, and other palladium-catalyzed cross-coupling reactions due to the reactive amine and halogen groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects requiring a specific, high-purity halogenated aniline derivative.

Basic Information

Product Name	6-Chloro-2-Fluoro-3-Methoxyaniline
CAS No.	1017777-77-3
Molecular Formula	C7H7ClFNO
Molecular Weight	175.59 g/mol
Synonyms	3-Methoxy-6-chloro-2-fluoroaniline; 2-Fluoro-6-chloro-3-methoxyaniline; 2-Fluoro-3-methoxy-6-chloroaniline; 6-Chloro-2-fluoro-3-methoxybenzenamine; 1-Amino-2-chloro-5-fluoro-6-methoxybenzene; Benzenamine, 6-chloro-2-fluoro-3-methoxy-; (6-Chloro-2-fluoro-3-methoxyphenyl)amine
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-2-Fluoro-3-Methoxyaniline is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure compliance with your project specifications. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.