Description

2,4-Dichloro-n-Cyclopropylpyrimidine-5-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine carboxamide core and cyclopropyl substituent. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of antiviral and anticancer agents, where its specific halogenated structure enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs targeting specific biological pathways.
• Antiviral Drug Development: Used in research and production of compounds designed to inhibit viral replication enzymes.
• Oncology Research: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapeutics.
• Agrochemical Synthesis: Potential intermediate for creating new generation fungicides or herbicides with specific modes of action.
• Chemical Biology & Proteomics: Utilized as a molecular probe or tag in studying protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	2,4-Dichloro-n-Cyclopropylpyrimidine-5-Carboxamide
CAS No.	1017464-37-7
Molecular Formula	C8H7Cl2N3O
Molecular Weight	232.07 g/mol
Synonyms	2,4-Dichloro-N-cyclopropylpyrimidine-5-carboxamide; 5-Pyrimidinecarboxamide, 2,4-dichloro-N-cyclopropyl-; N-Cyclopropyl-2,4-dichloropyrimidine-5-carboxamide; 2,4-Dichloro-N-cyclopropyl-5-pyrimidinecarboxamide; 2,4-Dichloro-5-(cyclopropylcarbamoyl)pyrimidine; 1017464-37-7 (CAS Name)
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-n-Cyclopropylpyrimidine-5-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.