Description

Cyclo(Phe-Hpro) is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), derived from the amino acids Phenylalanine (Phe) and Hydroxyproline (Hpro). This compound is of significant interest in pharmaceutical research and development due to its constrained, bioactive scaffold which can mimic protein secondary structures. It serves as a crucial building block and intermediate for medicinal chemists, particularly in the design of novel drug candidates targeting various therapeutic areas. The product is supplied with the CAS Registry Number 1016899-94-7.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and peptidomimetics.
• Medicinal Chemistry Research: Used as a privileged scaffold in drug discovery programs for designing molecules with improved metabolic stability and bioavailability.
• Bioconjugation & Probe Development: Serves as a linker or functional handle in the development of biochemical probes, diagnostic tools, and antibody-drug conjugates (ADCs).
• Peptide Library Synthesis: An essential component for constructing focused libraries of cyclic peptides for high-throughput screening against biological targets.
• Academic & R&D Laboratories: Utilized in universities and contract research organizations (CROs) for fundamental studies in organic chemistry and peptide science.

Basic Information

Item	Details
Product Name	Cyclo(Phe-Hpro)
CAS No.	1016899-94-7
Molecular Formula	C14H16N2O3
Molecular Weight	260.29 g/mol
Synonyms	Cyclo(L-phenylalanyl-trans-4-hydroxy-L-prolyl); 3-Benzyl-6-(hydroxymethyl)piperazine-2,5-dione; (3S,6S)-3-Benzyl-6-(hydroxymethyl)piperazine-2,5-dione; Cyclo(Phenylalanine-Hydroxyproline); Phe-Hpro Diketopiperazine; DKP-Phe-Hpro; Cyclo(L-Phe-trans-4-Hyp)
EINECS	Contact for details

Quality Control

Our Cyclo(Phe-Hpro) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades, including GMP standards for advanced clinical applications, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.