Description

Cyclo(Hpro-Leu) CAS NO 1016899-93-6 is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), derived from the amino acids hydroxyproline (Hpro) and leucine (Leu). This compound is of significant interest in pharmaceutical research and development due to its potential as a molecular scaffold and its role in modulating biological activity. It is primarily utilized by researchers and manufacturers in the life sciences sector for drug discovery, peptide chemistry, and as a building block for more complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Research: Used as a constrained scaffold in peptide mimetics to study structure-activity relationships and improve metabolic stability.
• Biochemical Tool: Employed in biochemical assays and as a reference standard for analytical method development and validation.
• Medicinal Chemistry: Acts as a core structure for designing protease inhibitors, receptor modulators, and other therapeutic agents.
• Cosmetic Peptides: Investigated for potential applications in advanced skincare formulations targeting specific biological pathways.

Basic Information

Product Name	Cyclo(Hpro-Leu)
CAS No.	1016899-93-6
Molecular Formula	C11H16N2O3
Molecular Weight	224.26 g/mol
Synonyms	Cyclo(Hyp-Leu); Cyclo(trans-4-Hydroxy-L-prolyl-L-leucyl); (3S,6S,9aS)-3-(2-Methylpropyl)-6-(hydroxymethyl)octahydropyrrolo[1,2-a]pyrazine-1,4-dione; 1,4-Diazabicyclo[4.3.0]nonane-2,5-dione derivative; Diketopiperazine Cyclo(Hyp-Leu); Hpro-Leu Cyclic Dipeptide; L-Leucyl-trans-4-hydroxy-L-proline Cyclic Anhydride
EINECS	Contact for details

Quality Control

Our Cyclo(Hpro-Leu) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.