Description

Fmoc-L-β-Homo-Cha-Oh CAS NO 1016276-93-9 is a protected, non-natural amino acid derivative featuring a cyclohexylalanine (Cha) side chain with a homologue (β-homo) backbone modification. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides with enhanced metabolic stability and altered conformational properties. It is primarily utilized by research scientists and process chemists in pharmaceutical R&D and biotechnology for developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of complex peptide sequences.
• Peptidomimetic Drug Discovery: Used to incorporate a constrained, hydrophobic cyclohexyl side chain with a modified backbone to improve peptide stability, bioavailability, and receptor binding affinity.
• Structure-Activity Relationship (SAR) Studies: Essential for probing the importance of side chain hydrophobicity and backbone length in peptide-protein interactions.
• Bioconjugation and Labeling: Serves as a specialty component for creating custom peptides used in diagnostic assays or targeted drug delivery systems.
• Academic and Industrial Research: A valuable tool in biochemistry and medicinal chemistry laboratories for exploring novel peptide architectures.

Basic Information

Product Name	Fmoc-L-β-Homo-Cha-Oh
CAS No.	1016276-93-9
Molecular Formula	C₂₆H₃₁NO₄
Molecular Weight	421.53 g/mol
Synonyms	Fmoc-β-homo-L-cyclohexylalanine; Fmoc-L-β-homo-Cha-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-homo-L-cyclohexylalanine; Fmoc-β-hCha-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-cyclohexylbutanoic acid; Fmoc-L-3-amino-4-cyclohexylbutyric acid; Fmoc-(β-homo)-L-Cha; Nα-Fmoc-β-homo-L-cyclohexylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homo-Cha-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.