Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-4(1H)-One (Wx130307) is a high-value, advanced pharmaceutical intermediate featuring a quinazolinone core functionalized with a pinacol boronate ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel drug candidates and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of targeted kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Enables rapid structure-activity relationship (SAR) exploration and library synthesis via palladium-catalyzed cross-coupling.
• Agrochemical Development: Used in the research and synthesis of novel active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Serves as a precursor for creating organic electronic materials and complex organic frameworks.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for methodological development and novel compound discovery.

Basic Information

Item	Detail
Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-4(1H)-One (Wx130307)
CAS No.	1009303-58-5
Molecular Formula	C₁₅H₁₉BN₂O₃
Molecular Weight	286.14 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydroquinazolin-4-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-ol; 6-(Pinacolboryl)quinazolin-4(1H)-one; Quinazolin-4(1H)-one, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; WX-130307; Wx130307
EINECS	Contact for details

Quality Control

Every batch of 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-4(1H)-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.