Description

1-Quinazolin-4-Yl-Pyrrolidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a fused heterocyclic structure that is critical for modern drug discovery. This compound serves as a versatile and valuable building block for the synthesis of novel bioactive molecules, particularly in the development of kinase inhibitors and other targeted therapies. It is essential for research and development teams in the pharmaceutical, biotechnology, and fine chemical sectors seeking to create new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in the development of assay probes and inhibitors for studying specific enzymatic pathways and biological targets.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex heterocyclic compounds in custom synthesis and contract manufacturing.
• Academic Research: Utilized in university and institutional labs for investigating new synthetic methodologies and chemical biology.

Basic Information

Product Name	1-Quinazolin-4-Yl-Pyrrolidine-2-Carboxylic Acid
CAS No.	1008675-45-3
Molecular Formula	C₁₃H₁₃N₃O₂
Molecular Weight	243.26 g/mol
Synonyms	4-(2-Pyrrolidinecarbonyl)quinazoline; Pyrrolidine-2-carboxylic acid quinazolin-4-yl ester; 1-(Quinazolin-4-yl)pyrrolidine-2-carboxylic acid; (2S)-1-(Quinazolin-4-yl)pyrrolidine-2-carboxylic acid (for stereoisomer); Quinazolinyl pyrrolidine carboxylate; 4-(Pyrrolidine-2-carbonyl)quinazoline; A building block for kinase inhibitors
EINECS	Contact for details

Quality Control

Our 1-Quinazolin-4-Yl-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities to meet the exacting standards of pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.