Description

Fmoc-L-Lys(Boc2-Aoa)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain functionality during the construction of complex peptides and peptidomimetics. It is primarily utilized in pharmaceutical R&D, particularly for developing therapeutic peptides, bioconjugates, and novel drug candidates where the lysine side chain must be selectively modified or labeled.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of lysine residues with protected side-chain amines, enabling sequential deprotection strategies.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Linker Chemistry: The protected aminooxyacetyl (Aoa) group on the lysine side chain provides a unique handle for site-specific conjugation with aldehydes or ketones, useful for attaching payloads, labels, or PEG chains.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Synthesis of Modified Peptides: Essential for producing peptides containing non-natural amino acids or specific post-translational modification mimics at lysine sites.

Basic Information

Product Name	Fmoc-L-Lys(Boc2-Aoa)-Oh
CAS No.	1008512-23-9
Molecular Formula	C₃₃H₄₅N₃O₉
Molecular Weight	627.73 g/mol
Synonyms	Fmoc-Lys(Boc2-Aoa)-OH; Nα-Fmoc-Nε-[(Ntert-butoxycarbonyl)aminooxyacetyl]-L-lysine; Fmoc-Lys(Nε-Boc-Aoa)-OH; Fmoc-Lys(Boc-Aoa)-OH; (2S)-6-[[(2-{[(tert-Butoxy)carbonyl]amino}oxy)acetyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; N-α-Fmoc-N-ε-(N-Boc-aminooxyacetyl)-L-lysine; Fmoc-Lys(Boc2-Aoa)-OH; Boc-Aoa-Lys(Fmoc)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-Lys(Boc2-Aoa)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are characterized by advanced techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing specific batch results is provided with each shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.