Description

4-Ethynyl-2-Fluorobenzenamine is a high-purity fluorinated aniline derivative featuring a reactive ethynyl group. This compound is a critical pharmaceutical intermediate and organic building block used in the synthesis of complex molecules. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Chemical Research: A versatile reagent in organic synthesis, including Sonogashira coupling and other palladium-catalyzed reactions, due to its terminal alkyne functionality.
• Ligand Precursor: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: An important compound for studying structure-activity relationships (SAR) in medicinal chemistry and the effects of fluorine substitution.

Basic Information

Product Name	4-Ethynyl-2-Fluorobenzenamine
CAS No.	1008112-39-7
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	2-Fluoro-4-ethynylaniline; 4-Amino-3-fluorophenylacetylene; 4-Ethynyl-2-fluoroaniline; 2-Fluoro-4-ethynylbenzenamine; 3-Fluoro-4-aminophenylacetylene; 4-Ethynyl-2-fluorophenylamine; Benzenamine, 4-ethynyl-2-fluoro-
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-2-Fluorobenzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	Light yellow to brown solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.