Description

1-[4-(Trifluoromethyl)Pyrimidin-2-Yl]-1H-Pyrazole-3-Carboxylic Acid is a high-value heterocyclic building block featuring a pyrazole-carboxylic acid moiety linked to a trifluoromethyl-substituted pyrimidine ring. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents, particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology: Serves as a versatile scaffold for probing biological pathways and protein-ligand interactions.
• Material Science: Potential precursor for specialty polymers or organic electronic materials due to its conjugated structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Pyrimidin-2-Yl]-1H-Pyrazole-3-Carboxylic Acid
CAS No.	1006492-26-7
Molecular Formula	C9H5F3N4O2
Molecular Weight	258.16 g/mol
Synonyms	1H-Pyrazole-3-carboxylic acid, 1-[4-(trifluoromethyl)-2-pyrimidinyl]-; 1-(4-(Trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxylic acid; 1-(4-Trifluoromethyl-pyrimidin-2-yl)-1H-pyrazole-3-carboxylic acid; 2-(3-Carboxy-1H-pyrazol-1-yl)-4-(trifluoromethyl)pyrimidine; 1006492-26-7
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Pyrimidin-2-Yl]-1H-Pyrazole-3-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be handled with appropriate precautions to avoid contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.